Mesothelioma
Stage Information
Patients
with stage I disease have a significantly better
prognosis than those with more advanced stages. However,
because of the relative rarity of this disease, exact
survival information based upon stage is limited.[1]
A proposed staging system based upon thoracic surgery
principles and clinical data is shown below.[2]
It is a modification of the older system proposed by
Butchart et al.[3] Other
staging systems that have been employed, including a
proposed new international TNM staging system, are
summarized by the International Mesothelioma Interest
Group.[4]
- Stage
I: Disease confined within the capsule of the
parietal pleura: ipsilateral pleura, lung,
pericardium, and diaphragm.
- Stage
II: All of stage I with positive intrathoracic (N1
or N2) lymph nodes.
- Stage
III: Local extension of disease into the following:
chest wall or mediastinum; heart or through the
diaphragm, peritoneum; with or without extrathoracic
or contralateral (N3) lymph node involvement.
- Stage
IV: Distant metastatic disease.
Localized
malignant mesothelioma
See
description of stage I above.
Advanced
malignant mesothelioma
See
descriptions of stages II, III, and IV above.
For the
purposes of the discussion of treatment in this summary,
the disease is categorized as either localized or
advanced.
References
- Chahinian
AP, Pass HI: Malignant mesothelioma. In: Holland JC,
Frei E, eds.: Cancer Medicine e.5. 5th ed. Hamilton,
Ontario: B.C. Decker Inc, 2000, pp 1293-1312.
- Sugarbaker
DJ, Strauss GM, Lynch TJ, et al.: Node status has
prognostic significance in the multimodality therapy
of diffuse, malignant mesothelioma. J Clin Oncol 11
(6): 1172-8, 1993. [PUBMED
Abstract]
- Butchart
EG, Ashcroft T, Barnsley WC, et al.:
Pleuropneumonectomy in the management of diffuse
malignant mesothelioma of the pleura. Experience
with 29 patients. Thorax 31 (1): 15-24, 1976. [PUBMED
Abstract]
- Rusch
VW: A proposed new international TNM staging system
for malignant pleural mesothelioma. From the
International Mesothelioma Interest Group. Chest 108
(4): 1122-8, 1995. [PUBMED
Abstract]
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Sources of National Cancer Institute Information
Mesothilioma, Mesotheliema,Mesothiliema,Mesotheleoma
Mesosthelioma, Masesthilioma information: |
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